Deformations and dilations of chaotic billiards, dissipation rate, and quasi-orthogonality of the boundary wavefunctions

We consider chaotic billiards in d dimensions, and study the matrix elements M_{nm} corresponding to general deformations of the boundary. We analyze the dependence of |M_{nm}|^2 on \omega = (E_n-E_m)/\hbar using semiclassical considerations. This relates to an estimate of the energy dissipation rate when the deformation is periodic at frequency \omega. We show that for dilations and translations of the boundary, |M_{nm}|^2 vanishes like \omega^4 as \omega -> 0, for rotations like \omega^2, whereas for generic deformations it goes to a constant. Such special cases lead to quasi-orthogonality of the eigenstates on the boundary.Comment: 4 pages, 3 figure

Investigation of the reinforcement of ductile metals with strong, high modulus discontinuous brittle fibers Quarterly report

Factors affecting reinforcement of aluminum with boron carbide whisker

Parametric Evolution for a Deformed Cavity

We consider a classically chaotic system that is described by a Hamiltonian H(Q,P;x), where (Q,P) describes a particle moving inside a cavity, and x controls a deformation of the boundary. The quantum-eigenstates of the system are |n(x)>. We describe how the parametric kernel P(n|m) = , also known as the local density of states, evolves as a function of x-x0. We illuminate the non-unitary nature of this parametric evolution, the emergence of non-perturbative features, the final non-universal saturation, and the limitations of random-wave considerations. The parametric evolution is demonstrated numerically for two distinct representative deformation processes.Comment: 13 pages, 8 figures, improved introduction, to be published in Phys. Rev.

Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis.

Although topical glucocorticoids (GCs) show potent anti-inflammatory activity in inflamed skin, they can also exert numerous harmful effects on epidermal structure and function. In contrast, topical applications of ligands of peroxisome proliferator-activated receptor-α (PPARα) not only reduce inflammation but also improve cutaneous barrier homeostasis. Therefore, we examined whether sequential topical GCs followed by topical Wy14643 (a ligand of PPARα) might be more effective than either alone for atopic dermatitis (AD) in a hapten (oxazolone (Ox))-induced murine model with multiple features of AD (Ox-AD). Despite expected anti-inflammatory benefits, topical GC alone induced (i) epidermal thinning; (ii) reduced expression of involucrin, loricrin, and filaggrin; and (iii) allowed outside-to-inside penetration of an epicutaneous tracer. Although Wy14643 alone yielded significant therapeutic benefits in mice with mild or moderate Ox-AD, it was less effective in severe Ox-AD. Yet, topical application of Wy14643 after GC was not only significantly effective comparable with GC alone, but it also prevented GC-induced structural and functional abnormalities in permeability barrier homeostasis. Moreover, rebound flares were largely absent after sequential treatment with GC and Wy14643. Together, these results show that GC and PPARα ligand therapy together is not only effective but also prevents development of GC-induced side effects, including rebound flares, in murine AD

secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila

Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epithelia to ions like chloride. In insects, the chloride channel mediating the effects of diuretic hormones was unknown. Surprisingly, we find a pentameric, cys-loop chloride channel, a type of channel normally associated with neurotransmission, mediating hormone-induced transepithelial chloride conductance. This discovery is important because: 1) it describes an unexpected role for pentameric receptors in the membrane permeability of secretory epithelial cells, and 2) it suggests that neurotransmitter-gated ion channels may have evolved from channels involved in secretion

On fundamental domains and volumes of hyperbolic Coxeter-Weyl groups

We present a simple method for determining the shape of fundamental domains of generalized modular groups related to Weyl groups of hyperbolic Kac-Moody algebras. These domains are given as subsets of certain generalized upper half planes, on which the Weyl groups act via generalized modular transformations. Our construction only requires the Cartan matrix of the underlying finite-dimensional Lie algebra and the associated Coxeter labels as input information. We present a simple formula for determining the volume of these fundamental domains. This allows us to re-produce in a simple manner the known values for these volumes previously obtained by other methods.Comment: v2: to be published in Lett Math Phys (reference added, typo corrected

Statistical Properties of Random Banded Matrices with Strongly Fluctuating Diagonal Elements

The random banded matrices (RBM) whose diagonal elements fluctuate much stronger than the off-diagonal ones were introduced recently by Shepelyansky as a convenient model for coherent propagation of two interacting particles in a random potential. We treat the problem analytically by using the mapping onto the same supersymmetric nonlinear $\sigma-$model that appeared earlier in consideration of the standard RBM ensemble, but with renormalized parameters. A Lorentzian form of the local density of states and a two-scale spatial structure of the eigenfunctions revealed recently by Jacquod and Shepelyansky are confirmed by direct calculation of the distribution of eigenfunction components.Comment: 7 pages,RevTex, no figures Submitted to Phys.Rev.

Localization in Strongly Chaotic Systems

We show that, in the semiclassical limit and whenever the elements of the Hamiltonian matrix are random enough, the eigenvectors of strongly chaotic time-independent systems in ordered bases can on average be exponentially localized across the energy shell and decay faster than exponentially outside the energy shell. Typically however, matrix elements are strongly correlated leading to deviations from such behavior.Comment: RevTeX, 5 pages + 3 postscript figures, submitted to Phys. Rev. Let

Quantum-Mechanical Non-Perturbative Response of Driven Chaotic Mesoscopic Systems

Consider a time-dependent Hamiltonian $H(Q,P;x(t))$ with periodic driving $x(t)=A\sin(\Omega t)$. It is assumed that the classical dynamics is chaotic, and that its power-spectrum extends over some frequency range $|\omega|<\omega_{cl}$. Both classical and quantum-mechanical (QM) linear response theory (LRT) predict a relatively large response for $\Omega<\omega_{cl}$, and a relatively small response otherwise, independently of the driving amplitude $A$. We define a non-perturbative regime in the $(\Omega,A)$ space, where LRT fails, and demonstrate this failure numerically. For $A>A_{prt}$, where $A_{prt}\propto\hbar$, the system may have a relatively strong response for $\Omega>\omega_{cl}$, and the shape of the response function becomes $A$ dependent.Comment: 4 pages, 2 figures, revised version with much better introductio